Denamarin^®

The #1 veterinarian recommended liver support brand.^†
Two actives, one patented formula
Denamarin is a supplement for dogs and cats containing S-Adenosylmethionine (SAMe) and silybin
Available in sizes for cats & small dogs, medium dogs, and large dogs

Now in Stable Chewable Tablets for Dogs!

Advanced technology in the exclusive NMXSS75™ S-Adenosylmethionine found in the new chewable formulations provides stability eliminating the need for enteric coating or foil-on-foil blistering. The chewable tablets for dogs are tasty, single size and scored for easy administration.

How does Denamarin work?

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly.

Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione,^1,2 an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death^3,4 and may help cell repair and regeneration.⁵

Denamarin also helps support your pet’s liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

The new chewable tablets of Denamarin allow dogs to receive SAMe and silybin in a tasty treat, eliminating the need to "pill" your dog daily. Additionally, the chewable tablets allow for quicker uptake of the SAMe and less variability between dogs when compared to enteric-coated tablets.

While best known for supporting the liver in dogs and cats Denamarin also has a place in supporting brain health. Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance.

Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for improvements in your pet’s attitude, appetite, and activity level.

Denamarin is only available from your veterinarian. Please consult your veterinarian to see if Denamarin is right for your pet.

Administration: Denamarin Tablets

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.^1,2 Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denamarin can be used in conjunction with Marin^®to provide additional silybin levels and the benefits of vitamin E and zinc supplementation. If Marin is used in conjunction with Denamarin, the two products should be administered 12 hours apart for best response.

Feline and Canine Denamarin Daily* Administration Guide

Denamarin For Cats and Small Dogs Contains 90 mg of S-Adenosylmethionine and 9 mg of silybin A+B
Body Weight	Body Weight	Number of Tablets Per Day
Up to 12 lbs	Up to 5.5 kg	1 tablet

Denamarin For Medium Dogs Contains 225 mg of S-Adenosylmethionine and 24 mg of silybin A+B
Body Weight	Body Weight	Number of Tablets Per Day
13-34 lbs	6-15.5 kg	1 tablet

Denamarin For Large Dogs Contains 425 mg of S-Adenosylmethionine and 35 mg of silybin A+B
Body Weight	Body Weight	Number of Tablets Per Day
35-65 lbs	16-29.5 kg	1 tablet
66-120 lbs	30-54.5 kg	2 tablets
Over 120 lbs	Over 54.5 kg	3 tablets

*The number of tablets can be gradually reduced or increased at any time depending on the pet’s needs. Many pets are maintained long-term on every-other-day or every third-day administration.

Storage

Store in a cool dry place not to exceed 86° F. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.

1. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.

2. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.

Administration: Denamarin Chewable Tablets (for dogs)

Denamarin Chewable Tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. The number of chewable tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.

For Dogs of All Sizes
Body Weight	Number of Chewable Tablets Per Day
Up to 6 lbs	¼
7-15 lbs	½
16-30 lbs	1
31-45 lbs	1 ½
46-60 lbs	2
61-75 lbs	2 ½
76-90 lbs	3
91-105 lbs	3 ½
Over 105 lbs	4