Denosyl for Dogs

  • Contains SAMe (S-Adenosylmethionine) to support liver and brain health
  • Available in enteric-coated tablets for dogs and cats and tasty chewable tablets for dogs
Container of Cosequin

How does Denosyl® work?


Liver Information

Denosyl has been shown to markedly increase liver levels of glutathione,1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. Denosyl has also been shown to help protect liver cells from cell death3,4 and may help cell repair and regeneration.5

Brain Information

While best known for supporting the liver in dogs and cats Denosyl also has a place in supporting brain health! Denosyl could help your best friend live a longer, healthier life.

Research is looking into dog aging and associated decreases in levels of SAMe (S-Adenosylmethionine) in cerebrospinal fluid, which surrounds the brain. Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

The chewable tablets of Denosyl allow dogs to receive SAMe in a tasty treat eliminating the need to "pill" your dog daily. Additionally, the chewable tablets are absorbed more quickly when compared to hard enteric-coated tablets.

Advanced technology in the exclusive NMXSS75® S-Adenosylmethionine found in the new chewable formulations provides stability eliminating the need for enteric coating or foil-on-foil blistering. The chewable tablets for dogs are tasty, single size and scored for easy administration.

Administration: Denosyl Tablets

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.6,7 Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide
For Cats and Small Dogs (90 mg)
Body Weight ) Body Weight Number of Tablets Per Day
Up to 12 lbs Up to 5.5 kg 1 tablet
For Medium Dogs (225 mg)
Body Weight Body Weight Number of Tablets Per Day
13-34 lbs 6-15.5 kg 1 tablet
For Large Dogs (425 mg)
Body Weight Body Weight Number of Tablets Per Day
35-65 lbs 16-29.5 kg 1 tablet
66-120 lbs 30-54.5 kg 2 tablets
Over 120 lbs Over 54.5 kg 3 tablets

*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.

Storage

Store in a cool dry place not to exceed 86° F. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.

Administration: Denosyl Chewable Tablets

The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest 1/2 tablet size.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine.

For Dogs of All Sizes
Body Weight Number of Chewable Tablets Per Day
Up to 6 lbs ¼
7-15 lbs ½
16-30 lbs 1
31-45 lbs 1 ½
46-60 lbs 2
61-75 lbs 2 ½
76-90 lbs 3
91-105 lbs 3 ½
Over 105 lbs 4

References

  1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
  2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
  3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
  4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
  5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
  6. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
  7. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.

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This product can be purchased
 through your veterinarian.

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