Released: Released: 4/3/2008

New Research Provides Further Evidence that Avocado/Soybean Unsaponifiables (ASU), Glucosamine, and Chondroitin Sulfate Benefit Joint Health


Edgewood, MD: Nutramax Laboratories, Inc. is pleased to announce results of exciting research presented in March at the 2008 Veterinary Orthopedic Society Annual Meeting. The results showed that the combination of avocado/soybean unsaponifiables (ASU), glucosamine hydrochloride, and chondroitin sulfate is effective at decreasing expression and production of agents involved in cartilage and tendon discomfort while also inhibiting the breakdown of cartilage. These in vitro studies expand on earlier research demonstrating ASU, glucosamine, and chondroitin sulfate’s effects in supporting and protecting joint health.

The first study used equine cartilage cells and showed that the combination of NMX1000® avocado/soybean unsaponifiables, FCHG49® glucosamine hydrochloride, and TRH122® low molecular weight chondroitin sulfate decreased expression of Substance P, which is a mediator thought to be related to joint discomfort. In the second study, production of another mediator, prostaglandin E2 (PGE2), and expression of its enzyme regulator cyclooxygenase-2 were also reduced by the ASU, glucosamine, and chondroitin sulfate combination; this work was done with equine tendon cells.

Lastly, results were presented from research done in bovine cartilage explants. PGE2 production and release of aggrecan, which is an indicator of cartilage breakdown, were lowered by the ASU, glucosamine, and chondroitin sulfate combination. This study showed the protective effects of the agents.

"We are very happy with these results," said Carmelita G. Frondoza, PhD, director of research and development. "They provide further evidence to both veterinarians and horse and pet owners that the use of ASU, glucosamine, and chondroitin sulfate is an excellent choice to help the management of joint comfort and health."

NMX1000® avocado/soybean unsaponifiables, FCHG49® glucosamine hydrochloride, and TRH122® low molecular weight chondroitin sulfate are found combined with methylsulfonylmethane (MSM) in the advanced joint health supplement for horses, Cosequin® ASU. For small animals, NMX1000 avocado/soybean unsaponifiables, FCHG49 glucosamine hydrochloride, and TRH122 low molecular weight chondroitin sulfate are found exclusively in the joint health supplement Dasuquin® for Dogs tasty chewable tablets and Dasuquin for Cats. For more information, please call Nutramax Laboratories, Inc. at (800) 925-5187 or visit www.nutramaxlabs.com

About Nutramax Laboratories, Inc.:
From the makers of Cosequin®, the #1 veterinarian-recommended joint health supplement brand**, come the equine formulation Cosequin ASU and Dasuquin®, the next generation in joint health support for dogs and cats. Other products include Denosyl®, Marin®, and the combination product Denamarin® for hepatic support; Welactin®, to help support skin and coat health plus overall wellness in dogs and cats; Oxstrin® and new Oxstrin Optimized Feline for maintenance of oxidative balance; Consil® Dental and Consil® Orthopedic synthetic bone graft particulate; and CoMal® Q10. Ask us about new Proviable(TM) multi-strain probiotic products for dogs and cats. For more information, call (800) 925-5187 or visit www.nutramaxlabs.com

Cosequin® ASU and Dasuquin® contain FCHG49® Glucosamine Hydrochloride, TRH122® Low Molecular Weight Sodium Chondroitin Sulfate, and NMX1000® Avocado/Soybean Unsaponifiables, Nutramax Laboratories® exclusive proprietary researched specifications.
U.S. Patent No. 6,797,289. Additional Patent Pending.
**Source: Surveys conducted in the Fall of 2002, March 2004, and September 2007 of equine veterinarians who recommended oral joint health supplements. Surveys conducted in October 2001, March 2004, and February 2007 of small animal veterinarians who recommended oral joint health supplements.


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