Frequently Asked Questions
How much Denamarin should I give my pet?
The administration guide below is provided as a general
recommendation, but your veterinarian will advise you as to the
amount to initially administer. Depending on your pet’s response
and status, your veterinarian may eventually adjust this amount
to meet your pet’s individual needs. Remember, Denamarin tablets
should not be broken. When increasing or decreasing the
administration, adjustments should be done in full tablet
increments. Some pets are given Denamarin only for a short
period of time, while Denamarin may be used longer periods of
time in other animals.
DAILY ADMINISTRATION GUIDE:
FELINE AND CANINE DENAMARIN DAILY* ADMINISTRATION GUIDE
For Cats and Small Dogs
| Body Weight |
# Tablets |
| Pounds |
Kilograms |
One tablet |
| Up to 12 |
Up to 5.5 |
For Medium Dogs
| Body Weight |
# Tablets |
| Pounds |
Kilograms |
One tablet |
| 13 to 34 |
6 to 15.5 |
For Large Dogs
| Body Weight |
# Tablets |
| Pounds |
Kilograms |
One tablet |
| 35 to 65 |
16 to 29.9 |
| 66 to 120 |
30 to 54.5 |
Two tablets |
| Over 120 |
Over 54.5 |
Three tablets |
*The number of tablets can be gradually reduced or increased at any
time depending on the pet’s needs. Many pets are maintained
long-term on every-other-day or every-third-day administration.
How will I know if Denamarin is helping my pet?
Your veterinarian will likely recommend follow-up examinations,
blood work, and/or other laboratory work to check on how well
your pet is doing with Denamarin and how it may help to improve
your pet’s liver function. At home, watch for improvements in
attitude, appetite, and activity level.
Are there any side effects?
There are no known side effects from Denamarin administration
and the active ingredients in Denamarin have been shown to be
well-tolerated by both dogs and cats with a wide margin of
safety. 1,2,3,4
Can Denamarin™ be used with other products?
Yes, your veterinarian may recommend combining Denamarin with
other products, like Marin®, and/or other dietary modifications.
Combining Marin with Denamarin provides added levels of silybin
along with vitamin E and zinc for those patients that may benefit
from additional liver support. There are no known interactions of
Denamarin with drugs or other supplements.
Are other brands the equivalent to Denamarin?
While other S-Adenosylmethionine and silybin products for
humans are available individually in health food stores and
over-the-counter in pharmacies, there can be a significant
variance in product quality and tablet strengths. Denamarin’s
active ingredients individually have been shown to be safe and
effective for both dogs and cats in published research studies and
have been combined in a single easy-to-administer tablet.
Denamarin also contains a specific silybin shown to provide better
bioavailability in dogs compared to the standardized milk thistle
commonly available in health food stores and over-the-counter in
pharmacies.
Since one of the actives in Denamarin is SAMe and that is
made from methionine, should I give my pet methionine?
Administration of methionine is not recommended. Providing high
levels of methionine to pets with liver compromise may not
increase the production of natural SAMe and has been shown in
some cases to increase liver damage.
If you have questions, please call (800) 925-5187 between the hours
of 8:30 a.m. and 5:00 p.m. Eastern Time, Monday through Friday to
speak to a Customer Service Representative or email us at
Contactus@nutramaxlabs.com.
REFERENCES
- Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
- Center SA, Warner K, Hoffman WE, et al. AJVR 2005;66:330-341.
- Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
- Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
- McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM
Forum 2003;abstract #134.
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