Denamarin is a liver and brain health supplement for dogs and cats containing S-Adenosylmethionine (SAMe) and silybin.

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential if function is to be improved.

Denamarin is now available in chewable tablets (for dogs)

• Contains exclusive stable NMXSS75™
  S-Adenosylmethionine (SAMe)
• Advanced technology in NMXSS75 SAMe provides stability eliminating the need for enteric coating or foil-on-foil blistering
• Quicker absorption of SAMe when compared to regular hard tablets
• Silybin in Denamarin complexed with phosphatidylcholine to increase bioavailability
• Designed as palatable, single size, scored chewable tablets for easy administration

Administering SAMe, which is found in Denamarin, has been shown to markedly increase liver glutathione levels,^1,2 a potent antioxidant formed when cats and dogs metabolize SAMe. The SAMe in Denamarin has also been shown to help protect liver cells from cell death^3,4 and may help cell repair and regeneration.⁵

Research is looking into dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Age related brain issues include confusion or personality changes often expressed through being less social.

Denamarin provides SAMe in a stablized form to help with brain health and act as a neuroprotector.

Denamarin also helps support your pet’s liver through the administration of silybin. Silybin is the most active part of an extract from milk thistle known as silymarin.

• Silybin/silymarin has been shown to support liver function by supporting oxidative balance.
• Silybin also stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet’s diet.
• Silybin also helps with liver cell regeneration and may enhance levels of glutathione.
• Silybin also reaches the brain tissue and may act as additional support for oxidative balance.

Denamarin has no known serious side-effects and your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, you can watch for improvements in your pet’s attitude, appetite, and activity level.

Denamarin is only available through your veterinarian. Please consult your veterianian to see if Denamarin is right for your pet.

If you have questions, please call (800) 925-5187 between the hours of 8:30 a.m. and 5:00 p.m. Eastern Time, Monday through Friday to speak to a Customer Service Representative or email us at Contactus@nutramaxlabs.com.

1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.