Released: 12/14/2007

Avocado/Soybean Unsaponifiables (ASU), Glucosamine, and Chondroitin Sulfate Shown Effective in Equine Cells at Protecting Cartilage

Edgewood, MD: Nutramax Laboratories, Inc. is pleased to announce results of cell culture research presented in October at the 2007 American College of Veterinary Surgeons Veterinary Symposium in Chicago. The results showed that the combination of avocado/soybean unsaponifiables (ASU), glucosamine hydrochloride, and chondroitin sulfate is effective in equine cartilage cells (chondrocytes) and bone cells (osteoblasts) at inhibiting expression and decreasing production of mediators involved in joint cartilage breakdown. This study expands on research demonstrating the compounds' effects in supporting and protecting joint health in other species (canine, feline, and human cells). The protective effects of the compounds may minimize cartilage breakdown by suppressing the release of the mediators responsible.

The study showed that the combination of NMX1000® avocado/soybean unsaponifiables, FCHG49® glucosamine hydrochloride, and TRH122® low molecular weight chondroitin sulfate decreased expression of the enzyme cyclooxygenase-2 that regulates the production of the mediator prostaglandin E2 (PGE2) in both equine chondrocytes and equine osteoblasts. Production of PGE2 was also reduced by up to 80% in chondrocytes and by 67% in osteoblasts versus control. Effects on osteoblasts are relevant to cartilage health as changes brought about by mediators on the bone underlying cartilage, known as subchondral bone, can lead to breakdown of cartilage.

"These results are very exciting," said Tara Cullen, equine product manager. "They provide further evidence to both veterinarians and horse owners that the use of ASU, glucosamine, and chondroitin sulfate is an excellent option in the management of joint health in horses."NMX1000® avocado/soybean unsaponifiables, FCHG49® glucosamine hydrochloride, and TRH122® low molecular weight chondroitin sulfate are found combined with methylsulfonylmethane (MSM) in the advanced joint health supplement for horses, Cosequin® ASU. For more information, please call Nutramax Laboratories, Inc. at (800) 925-5187 or visit

About Nutramax Laboratories, Inc.:
Nutramax Laboratories, Inc. markets the premier line of equine joint health supplements: Cosequin®, the #1 veterinarian recommended brand†. The Cosequin Equine family is made up of Cosequin ASU, a comprehensive, multi-faceted joint health management formula; Cosequin Optimized; Cosequin Optimized with MSM, and original Cosequin Concentrated Powder.

Dasuquin® is the combination of ASU with Cosequin's glucosamine hydrochloride and low molecular weight chondroitin sulfate for dogs and cats. For more information on these and our other veterinary products, call (800) 925-5187 or visit

Cosequin® ASU and Dasuquin® contain FCHG49® Glucosamine Hydrochloride, TRH122® Low Molecular Weight Sodium Chondroitin Sulfate, and NMX1000® Avocado/Soybean Unsaponifiables, Nutramax Laboratories® exclusive proprietary researched specifications.

U.S. Patent No. 6,797,289. Additional Patent Pending.

†Source: Surveys conducted in the Fall of 2002 and March 2004 of equine veterinarians who recommended oral joint health supplements. Surveys conducted in October 2001, March 2004 and February 2007 of small animal veterinarians who recommended oral joint health supplements.

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